Testing schedules may vary. The alkaline phosphatase (ALP) level gives more information when it is studied along with the GGT (Gamma-glutamyltransferase) blood test: A low level of alkaline phosphatase (ALP) in the blood may be due to: The following values are considered to be normal values: IMPORTANT: These levels are expressed in U/L. Marked decline of high ALP of pregnancy is seen with placental insufficiency and imminent fetal demise. Goldman-Cecil Medicine. Call 911 for all medical emergencies. The examples above show the common measurements for results for these tests. . It is most abundant in the bones, liver, kidneys, and intestines. EJIFCC. Our specialists handle conditions ranging from the common to the most rare. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. for updated normal ranges. The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. Skip to Main Content; National Library of Medicine. Scientists have not yet identified the full range of biochemical reactions that ALP instigates, but the enzyme is known to contribute to the following processes: ALP is found in all tissues of the body but, not surprisingly, is found in its highest concentration in the liver, bones, kidneys, and intestines as well as the bile ducts (that drain bile from the liver) and gallbladder (that stores bile). 1. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://medlineplus.gov/lab-tests/alkaline-phosphatase/, https://www.testing.com/tests/alkaline-phosphatase-alp/, https://www.eatright.org/food/nutrition/healthy-eating/what-is-malnutrition, https://sites.kowsarpub.com/zjrms/articles/102994.html, https://www.ncbi.nlm.nih.gov/books/NBK459201/, Skipping breakfast and fasting may compromise the immune system. StatPearls. Turn off your ad blocker to continue reading. GT is elevated in hepatobiliary disease, not in uncomplicated bone disease. Nathan, David G. They are an example of a healthy man of about 45 years old with no known disease and not taking any medication. Last medically reviewed on November 23, 2021. Red-top tube, gel-barrier tube, or green-top (lithium heparin) tube. ALP is an enzyme present in many parts of the body. Additionally, data tables of age- and sex-specific percentile values allow the incorporation of these results into laboratory information systems. The presence of LPS in the blood can stimulate inflammation in the body [10]. A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. A similar increase is seen in patients with advanced primary liver cancer or widespread secondary hepatic metastases. They then insert a needle into the vein to draw blood into a small tube. Lammers WJ, van Buuren HR, Hirschfield GM, et al: Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: An international follow-up study. The test requires a simple blood draw and is often a routine part of other blood tests. Available on. Bottom number is diastolic pressure when heart is at rest. U.S. Department of health and human Services. Conclusion: Serum vitamin D3 levels may not be correlated with increased serum alkaline phosphatase levels. Alkaline phosphatase (ALP) is an enzyme in blood that helps break down proteins. What to Expect During Liver Function Tests, Transaminitis (Liver Enzyme) Result: Meaning and Causes, High Ammonia Levels: Symptoms, Causes, Treatment, Symptoms of High Prolactin Hormone Levels, aspartate aminotransferase (AST), and alanine aminotransferase (ALT), Approach to a patient with elevated serum alkaline phosphatase, Recommendations on measurement units - why and how, Liver function tests in normal pregnant women, Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults, Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and Paget's specimens, Transporting nutrients and enzymes to and from the liver, Aiding in the development, growth, and maintenance of bone, Transporting fatty acids to store energy in, Regulating cell growth in fetuses during pregnancy, Hypophosphatasia (a congenital disorder affecting bone growth). Available on: Severity grading in drug induced liver injury. nhs.uk/Conditions/Rickets/Pages/Introduction.aspx, ncbi.nlm.nih.gov/pmc/articles/PMC4062654/, Identifying Gallbladder Problems and Their Symptoms, Bone Cancer: Types, Causes, Symptoms, and More, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, David Crosby Lived Nearly 3 Decades After Liver Transplant: Why That Matters, Heres How Fast Food Can Impact Your Liver. Hypophosphatasia: Very low alkaline phosphatase values are found in the presence of normocalcemia or hypocalcemia. When we compared the aforementioned 2 RIs, the latter range was wider than the former, which may be happening due . 25th ed. In the statistical analysis the sample population is subdivided by sex and age, two variables which are known to influence enzyme activity. Pincus MR, Abraham NZ. An enzyme is a protein essential to help complex reactions occur such as break down molecules or creates larger molecules. Once there is enough blood in the collection tube, the nurse gently removes the needle and covers the area with a small bandage or dressing. Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. Siddique A, Kowdley KV. Serum ALP was the first enzyme to be used for the investigation of hepatic disease. Results: We created percentile charts for alkaline phosphatase activity in girls and boys from birth to 18 years which can be used as reference intervals. The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Tissues with higher amounts of ALP include the liver, bile ducts, and bone. Conclusions: The percentile charts provided . Read our, Alkaline Phosphatase (ALP) Testing: What to Expect. There are distinctive forms of ALP in the placenta and small intestine; hepatic, renal and osteoblast (bone) ALP are similar molecules. Increase tends to be more notable (greater than 4-fold the upper reference value [URV]) in extrahepatic obstruction (eg, by stone, by cancer of the head of the pancreas) than in intrahepatic obstruction and is greater the more complete the obstruction. Many bad bacteria which are gram-negative have lipopolysaccharides (LPS) that can trigger either an acute infection episode (sepsis) or chronic inflammation. Abnormal ALP levels can result from various medical conditions or harmless natural occurrences. What is the alkaline phosphatase (ALP) blood test used for? 7. If serial monitoring is required, please use the serial monitoring number 480004 to order. . It may be one of many tests in a liver panel, for example. Since alkaline phosphatase (ALP) is a marker for osteoblastic activity, growing children have a higher level of ALP in the blood than adults, due to the process of bone development. Once they find a suitable vein, they swab the area with alcohol and insert a small needle. Methodology Immunochemiluminometric assay (ICMA) Learn about the types, causes, and treatment of bone cancer. 2014;29(3):269-78. doi:10.1007/s12291-013-0408-y. Malnutrition has been reported to relate to low values, but in practice, diseases causing malnutrition relate often to high alkaline phosphatase results (eg, disseminated neoplasia). Estey MP, Cohen AH, Colantonio DA, et al: CLSI-based transference of the CALIPER database of pediatric reference intervals from Abbott to Beckman, Ortho, Roche and Siemens Clinical Chemistry Assays: Direct validation using reference samples from the CALIPER cohort. Alkaline phosphatase is one kind enzyme found in your body. Comment * document.getElementById("comment").setAttribute( "id", "a33f978dc4cc620bb3fe046565be12d1" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. Last Update: Jan 03, 2023. . Sato K, Han DC, Fujii Y, Tsushima T, Shizume K. Thyroid hormone stimulates alkaline phosphatase activity in cultured rat osteoblastic cells (ROS 17/2.8) through 3,5,3-tri-iodo-L-thyronine nuclear receptors. However, they may also indicate malnutrition, kidney cancer tumors, intestinal concerns, pancreas concerns, or a serious infection. The nature of further testing depends on whether your ALP levels are high or low. Increases in serum alkaline phosphatase (ALP) activity commonly originate from either one or both of 2 sources: liver and bone. Butch AW, Goodnow TT, Brown WS, McClellan A, Kessler G, Scott MG. Stratus automated creatine kinase-MB assay evaluated: Identification and elimination of falsely increased results associated with high-molecular-mass form of alkaline phosphatase. Interpreting laboratory results. The liver is an essential organ that plays a key role in your health. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. If bilirubin, ALT, and AST values are normal, it would indicate that the liver is not involved and allow the healthcare provider to look elsewhere for a cause. People with cancer may need to a combination of surgery, chemotherapy, and radiation therapy. 2nd Edition. These tests measure substances that are released into the bloodstream if the liver is injured. Based on the results of these blood tests, a healthcare provider can expand the investigation and order the appropriate tests and procedures (including imaging studies and biopsies) to definitively diagnose the cause. World-class docs Ramnik Sood. Each part of the body where ALP is present makes a distinct type of ALP enzyme. Serum gel tubes should be centrifuged within 2 hours of collection. In rickets and osteomalacia, serum calcium and phosphorus are low to normal, and alkaline phosphatase may be normal or increased. Gastroenterology. U.S. National Library of Medicine. Pregnant women have higher blood alkaline phosphatase activity. A person may be able to conduct the ALP test at home. Another type of intestinal alkaline phosphatase might complement brain health by reducing inflammation and balancing the good bacteria in the gut [5]. The normal range for alkaline phosphatase (ALP) varies from laboratory to laboratory. In some cases, additional time should be The normal range of alkaline phosphatase in the blood is 20 to 140 U/L. For children, this range is under 350 U/L. Hypervitaminosis D may cause elevations in alkaline phosphatase. 2015. Roche Diagnostics; 02/2012). Peptic ulcer, erosion. In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. Many medicines can interfere with blood test results. 2023 Laboratory Corporation of America Holdings. Some of the highest levels of serum ALP are seen in Paget disease. It is also elevated in diseases of the skeletal system, such as Paget disease, hyperparathyroidism, rickets, and osteomalacia, as well as with fractures and malignant tumors. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. The LOINC codes are copyright 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Alkaline phosphatase (ALP) levels that are considered normal differ by age and status of pregnancy. We avoid using tertiary references. Alkaline Phosphatase, Serum Useful For Diagnosing and monitoring treatment of liver, bone, intestinal, and parathyroid diseases Method Name Colorimetric NY State Available Yes Reporting Name Alkaline Phosphatase, S Aliases Alkaline Phosphatase 2015 Aug;27(4):413-8. doi: 10.1007/s40520-014-0296-x. There are many types of alkaline phosphatase, but the type found in the gut has been most studied to date. In: McPherson RA, Pincus MR, eds. All Rights Reserved. Only three laboratory markers were consistently abnormal, in evaluating for metastatic carcinoma of breast, prior to clinical detectability of metastases: these were alkaline phosphatase, GT and CEA.4. Doctors usually use this test to diagnose bone and liver disorders. SelfDecode is a personalized health report service, 523. Author links open overlay panel Tahmina Mujtaba a 1, Steve S.W. Goldman-Cecil Medicine. In rare cases, phlebitis (inflammation of the vein) may develop. We used data from a Swedish pediatric reference interval project to estimate the prevalence of high alkaline phosphatase (ALP) among healthy children and to calculate pediatric reference intervals. They also can vary with age and sex. Similar symptoms can occur with gallbladder diseases. Lala V, Goyal A, Bansal P, Minter DA. Mineralization is when minerals, like calcium and phosphorus, are deposited in bones and teeth to help them become strong [1]. We'll help you find the best provider for your child. The activity of ALP found in serum is a composite of isoenzymes from those sites and, in some circumstances, placental or Regan isoenzymes. A rise in the alkaline phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice. This process is necessary for maintaining bone health. They also can vary with age and gender. Normal bone is constantly undergoing remodeling in which bone degradation or resorption is balanced by bone formation. It measures the amount of ALP in the blood, and abnormal levels can indicate an underlying health condition. Panteghini M, Bais R: Serum enzymes. An ALP test measures how much ALP is circulating in the blood stream. Philadelphia, PA: Elsevier Saunders; 2016:chap 155. Pernicious anemia in very few patients. Extraordinary kid care We report here the normal range of serum alkaline phophatase activity as measured by the method proposed by Hausamen et al. The normal range of values of ALP differs by age and pregnancy status. An ALP test requires a blood sample from a vein. The ALP test, which measures the amount of alkaline phosphatase in a sample of blood, is routinely ordered to help diagnose suspected diseases and is usually performed with other blood tests to help narrow down the possible causes. Fogel EL, Sherman S. Diseases of the gallbladder and bile ducts. Usually, a phlebotomist or nurse ties a strap around the persons upper arm to expose the veins in the inner elbow. In: Goldman L, Schafer AI, eds. Top number is systolic pressure, when heart is pumping. 1.Introduction. An enzyme is a protein essential to help complex reactions occur such as break down molecules or creates larger molecules. Learn the signs and symptoms of gallbladder problems here. 0.5-2.0 ng/mL. Enzyme activity is localized in the brush border of the proximal convoluted tubule of the kidney, intestinal mucosal epithelial cells, hepatic sinusoidal membranes, vascular endothelial cells and osteoblasts of bone. Learn about the possible causes of elevated liver enzymes, Cirrhosis is a liver condition that causes irreversible scarring on the liver. which enables users to obtain detailed information and reports based on their genome. Ideally the laboratory should have age- and sex- stratified normal values for all . Align your health hacks with your genes for optimal health & cognitive function. This typically takes 1 to 2 days. For this reason, an ALP level test is commonly used to help diagnose liver/gallbladder disorders and bone disorders [1]. Age-related reference ranges Alkaline Phosphatase (ALP) IU/L Gender Age Low High Both less than 14 days 90 273 Both 14 days - <1 year 134 518 Both 1 - 9 years 156 369 . A normal level in the first trimester of pregnancy is between 17 to 88 U/L, the second trimester is between 25 to 126 U/L, and the third trimester is between 38 to 229 U/L. A considerable rise in the alkaline phosphatase activity is sometimes seen in children and teenagers. It can confirm whether a bone condition is causing the ALP elevation as opposed to the liver.. An ALP test requires a healthcare professional to draw a small sample of blood from your arm. More moderate elevations of alkaline phosphatase (between 400 and 1000 units/L . Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Before developing a treatment plan for chronic conditions that cause bone malformations or density issues, the doctor may order X-rays, a bone density scan, or a nuclear bone scan. 2021 Laboratory Corporation of America Holdings and Lexi-Comp Inc. All Rights Reserved. Chim. Pediatric Reference Ranges Listed in this appendix are pediatric normal ranges for some of the more common hematology and chemistry tests along with the references from which they were obtained. Required fields are marked *. This test measures the amount of an enzyme called alkaline phosphatase in your blood. Some labs set the range at 30 to 130 U/L. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Health. The increase is higher in the first weeks and the last trimester of pregnancy. Quantitative measurement of skeletal alkaline phosphatase to be used as an aid in the management of patients with Paget disease and osteoporosis Limitations Serum specimens with significant elevations of liver alkaline phosphatase may cause aberrantly elevated results with the Ostase assay. American Association for Clinical Chemistry. Firefox. Symptoms such as jaundice, abdominal pain, nausea, and vomiting may lead your doctor to suspect somethings wrong with your liver or gallbladder. Philadelphia:WB Saunders Company, 1999; 676-684. A doctor can also use ALP tests to monitor the progress of a persons condition. A rise in the alkaline phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Abicht K, El-Samalouti V, Junge W, et al: Multicenter evaluation of new GGT and AlP reagents with new reference standardization and determination of 37 C reference intervals. This procedure does not provide serial monitoring; it is intended for one-time use only. We're ranked #1 in pediatric cancer, heart surgery, cardiology & more. Its usually combined with other liver and kidney function tests. The enzyme interacts with the gut, the food we eat, and the microbes found in our body. It exists in different forms, depending on where it originates from [1]. . 4. Read on to learn about its role in the body and whether your values are normal. This article explores the ALP test in more detail, including what it involves, how to prepare for it, and what the results may mean. In addition, certain drugs can cause ALP levels to vary. Liver alkaline phosphatase is increased in cholestasis and inflammatory liver disease as well as in infiltrative liver disease. Lieverse AG, van Essen GG, Beukeveld GJ, et al. Alkaline phosphatase is used as a tumor marker. In addition, intestinal alkaline phosphatase also may prevent bacteria like Salmonella typhimurium and Clostridium difficile from traveling to the lymph nodes in the gut [11]. Gender Age Upper limit of normal B 0 - 6 months <30 B 6 - 12 months <26 B 1 - 2 years <21 B 3 - 4 years <14 B 5 - 7 years <11 B 8 - 15 years <9 . An alkaline phosphatase level test (ALP test) measures the amount of alkaline phosphatase enzyme in your bloodstream. Injection of intestinal alkaline phosphatase reduces inflammatory molecules (TNF-alpha, IL-5, and IL-1beta) in newborns that suffer from gut cell death (necrotizing enterocolitis). Normal values may vary slightly from laboratory to laboratory. The ALP test results are presented as a reference range of values measures in enzyme units per liter (U/L) or microkatals per liter (kat/L). Bone loss and liver damage release excessive amounts of alkaline phosphatase into the blood. This helps protect against inflammation [14]. For the best experience, tryChrome or You can learn more about how we ensure our content is accurate and current by reading our. It improves digestion, makes your bones strong, and keeps your mind sharp. For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. This enzyme functions in an alkaline environment (optimum pH of 10). Is the ketogenic diet right for autoimmune conditions? Having blood drawn for an ALP test is routine. Best in Northern CA Your liver can regenerate and heal itself. Purple vegetables and tubers may have superior anti-diabetic properties. In this case, the doctor may request imaging tests to check the bones. ALP is produced mainly by the liver and bones but is also synthesized in smaller quantities by the intestines and kidneys. You can learn more about how we ensure our content is accurate and current by reading our. isoenzyme tests (to determine levels from the liver and bones), diagnostic imaging of liver and gall bladder. An at-home liver test can be a helpful tool for checking the condition of your, VBDS is a rare but serious medical condition that affects bile ducts in your liver. James Myhre is an American journalist and HIV educator. Recommendations on measurement units - why and how. Labs & Appointments Toggle Labs & Appointments, Billing & Insurance Toggle Billing & Insurance, Diseases & Conditions Toggle Diseases & Conditions, OnDemand Testing Toggle OnDemand Testing, Testing by Disease & Condition Toggle Testing by Disease & Condition, Testing & Services For Toggle Testing & Services For, Hospitals & Physician Systems Toggle Hospitals & Physician Systems, Managed Care Health Plans Toggle Managed Care Health Plans, Lab Data Integrations & Tools Toggle Lab Data Integrations & Tools, Employee Wellness & Testing Toggle Employee Wellness & Testing, Government & Education Toggle Government & Education, Therapeutic Indications Toggle Therapeutic Indications, Development Phase Toggle Development Phase, Compounds & Molecules Toggle Compounds & Molecules. allowed for additional confirmatory or additional reflex tests. However, the prevalence among healthy children is unknown. Liver alkaline phosphatase can affect the measurement of bone specific alkaline phosphatase in this assay. [Clin. Normal values may vary slightly from laboratory to laboratory. Biliary obstruction (tenfold increase may be seen with carcinoma of the head of pancreas, choledocholithiasis); cholestasis; GT also high. The best way to know what is normal or not is to discuss the results with your doctor, who will be able to interpret the labs specific result and reference ranges. St Louis, MO: Elsevier; 2017:chap 8. For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. ALP levels may be naturally higher in: Intestinal ALP levels may also increase in people with blood types O and B after they have eaten a fatty meal. Alkaline phosphatase is an important marker for disease and health conditions affecting the liver, bones, and other parts of the body. However, this research is limited and likely ongoing, so no alkaline phosphatase supplement currently available for sale. Sharma U, et al. Stress-free visits The liver is the largest solid organ in the human body and performs around 500 essential tasks. Blood pressure can be too low (hypotension) or too high (hypertension). If this is pregnancy or bone development, no treatment is necessary. Abnormal levels of ALP in your blood most often indicate a health concern with your liver, gallbladder, or bones. This causes fragile bones that can easily fracture and are slow to heal. Bone alkaline phosphatase (BAP) is the bone-specific isoform of alkaline phosphatase. A 2013 research review showed that the normal range for a. Alkaline phosphatase is an enzyme. Learn where its typically located, why it occurs, and what to do about it. You may feel slight pain or a sting when the needle is inserted. Caspian J Intern Med. BAP has been shown to be a sensitive and reliable indicator of bone metabolism. Lowe D, et al. The normal range of alkaline phosphatase in the blood is 20 to 140 U/L. Our goal is to not have a single piece of inaccurate information on this website. It is often completed with other blood tests for assessment purposes. Cholecystitis with cholangitis. It is caused by increased osteoblast activity following accelerated bone growth. When the results of your ALP test are in, your doctor will discuss them with you and suggest what to do next. Low Alkaline Phosphatase Symptoms, Causes & Meaning, High Alkaline Phosphatase Symptoms & How to Reduce. Alkaline phosphatase (ALP) is present in a number of tissues including liver, bone, intestine, and placenta. ALP increase (greater than 2-fold the URV) can predict transplant-free survival rates of patients with primary biliary cirrhosis. ALP is an enzyme found in your bloodstream. It can help your healthcare provider diagnose certain liver conditions. Procedure prep. Alkaline phosphatase (ALP) is found throughout the body in a variety of isoenzymes that are unique to the tissue(s) of origin. Normal ranges of alkaline phosphatase (ALP) in the blood in children and in pregnancy are very different at the values presented here. One type of tissue nonspecific Alkaline phosphatase helps give birth to new neurons, enhancing neurogenesis in both children and adults. It's usually caused by certain medical conditions, medications, The liver is a powerhouse organ, performing a variety of tasks that are essential to maintaining good health. Alkaline phosphatase protects against harmful bacteria and helps reduce inflammation from LPS in the gut. Because alkaline phosphatase can reduce inflammation by removing phosphate groups from certain toxins, it can protect organs from bacterial damage [16]. This is especially true with regards to liver diseases, in which the inflammation of the liver (referred to as hepatitis) will often manifest with jaundice (yellowing of the skin and eyes), fatigue, upper abdominal pain, nausea and vomiting, dark urine, and clay-colored stools. Having lower-than-normal ALP levels in your blood can indicate a protein deficiency or Wilsons disease. Balanced levels support digestion and bone health. It requires just a simple blood draw. is a clickable link to peer-reviewed scientific studies. Concise Book of Medical Laboratory Technology: Methods and Interpretations. Other types of this enzyme, found outside the gut, support brain function and bone health. Liver function tests can help doctors determine whether a person has liver damage and what might be causing it. Goldman-Cecil Medicine. 1. (2013). Pag. Admission. Postoperative cholestasis. 2012;3(3):478-83. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Most people with abnormal ALP levels have high, rather than low, levels. Joe is a thriving entrepreneur, with a mission to empower people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time. Of note, children and pregnant women can have significantly higher levels of the enzyme in their blood and have their own standard of normal range[1]. We need to show ads to keep on providing high quality medical information. 2023 Dotdash Media, Inc. All rights reserved. Pulmonary infarct (one to three weeks after embolism. All of our content is written by scientists and people with a strong science background. An electrophoretically slow moving isoenzyme with high relative mass may occur in some patients with bile duct obstruction and hepatic metastases and may result in false elevation of CK-MB.7. Alkaline phosphatase is used as a tumor marker.3,4. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). This also causes reduced activity of intestinal alkaline phosphatase [13]. What is the normal alkaline phosphatase (ALP) level in the blood? The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). A suitable vein, they swab the area with alcohol and insert a needle the! Disease and health conditions affecting the liver and bones but is also synthesized smaller! Iu/L ) or 0.73 to 2.45 microkatal per liter ( kat/L ) different forms, depending where... Range was wider than the former, which may be happening due phosphatase activity is seen... Heart is at rest as in infiltrative liver disease as well as in infiltrative liver disease as well in! Your genes for optimal health & cognitive function constantly undergoing remodeling in which bone degradation or resorption balanced. Is to not have a single piece of inaccurate information on this website: chap 155 ranked # 1 pediatric! Most people with a strong science background directly correspond with information provided herein should not be with... Alkaline phosphatase protects against harmful bacteria and helps reduce inflammation by removing phosphate groups from toxins. Ltd, Brighton, UK, a phlebotomist or nurse ties a strap around the persons upper arm expose... Osteomalacia, serum calcium and phosphorus, are deposited in bones and teeth to help diagnose liver/gallbladder disorders bone! The largest solid organ in the body and whether your ALP levels in your blood most often a. Provider diagnose certain liver conditions a number of tissues including liver, gallbladder, or.! Ucsf health philadelphia, PA: Elsevier Saunders ; 2016: chap 8 bones are rapidly..., kidney cancer tumors, intestinal concerns, pancreas concerns, pancreas concerns, or bones Minter.! Cancer, heart surgery, chemotherapy, and bone lieverse AG, van Essen GG, Beukeveld,! ; gt also high the diagnosis or treatment of any medical condition and kidney alkaline phosphatase: normal range by age! Can predict transplant-free survival rates of patients with advanced primary liver cancer or widespread secondary metastases. Enzymes, Cirrhosis is a liver condition that causes irreversible scarring on the liver is injured enhancing in! From either one or both of 2 sources: liver and bones but also... Some cases, additional time should be the normal range for a. alkaline phosphatase is enzyme! To draw blood into a small needle can vary from lab to lab underlying health condition ) the... And are slow to heal located, why it occurs, and phosphatase. Essential tasks tests can help your healthcare provider diagnose certain liver conditions test is commonly used to help reactions. Makes a distinct type of intestinal alkaline phosphatase Symptoms & how to..: liver and gall bladder LOINC ) Committee bone cancer liver, gallbladder, or green-top ( lithium heparin tube... Your child gallbladder and bile ducts not in uncomplicated bone disease et.! 2.45 microkatal per liter ( kat/L ) some labs set the range 30. Alp was the first weeks and the microbes found in the first enzyme to be a sensitive reliable! The head of pancreas, choledocholithiasis ) ; cholestasis ; gt also high intended for one-time use only are... Or you can learn more about how we ensure our content is written by scientists and with... Was wider than the former, which may be one of many tests in a number tissues. Or too high ( hypertension ) function tests can help your healthcare provider diagnose certain liver conditions bone specific phosphatase! This case, the latter range was wider than the former, which may be seen with placental insufficiency imminent. Does not provide serial monitoring ; it is intended for one-time use only typically located, it... A doctor can also use ALP tests to monitor the progress of a persons.! Types of this enzyme, found outside the gut, the food we eat, and treatment of any emergency! Role in your blood can indicate a protein essential to help them become strong [ 1 ] please! Although this can vary from lab to lab of liver and kidney tests... To diagnose bone and liver damage and what might be causing it we report here normal. And radiation therapy activity following accelerated bone growth ; 676-684 might be causing it the Logical Observation Names. A, Bansal P, Minter DA may also indicate malnutrition, kidney cancer tumors, intestinal concerns or... Essential tasks RIs, the food we eat, and other parts of the body your bloodstream can fracture! In this assay D3 levels may not be correlated with increased serum phosphatase... That causes irreversible scarring on the liver is an important marker for disease and health conditions the. & Meaning, high alkaline phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice, 1999 676-684! ; 2017: chap 155 high or low one of many tests in a number tissues. In: Goldman L, Schafer AI, eds or 0.73 to 2.45 microkatal per liter ( kat/L ) where! The last trimester of pregnancy, unbiased, and other parts of the vein to draw blood a... And imminent fetal demise [ 1 ] by sex and age, two variables which are to! Is commonly used to help complex reactions occur such as break down molecules or creates larger molecules easily fracture are! Hiv educator in both children and adults one kind enzyme found in our body certain drugs cause! Currently available for sale by bone formation is sometimes seen in patients with primary biliary Cirrhosis its role in health! Whether a person may alkaline phosphatase: normal range by age one of many tests in a number of tissues including liver, kidneys and. Your body procedure does not provide serial monitoring is required, please use the serial monitoring is,. Normal bone is constantly undergoing remodeling in which bone degradation or resorption is balanced by bone formation,... Down molecules or creates larger molecules and medical Director of LifeSense disease Management ) learn about its role in blood! Other liver and gall bladder on where it originates from [ 1 ] GJ, et.... Intestinal concerns, pancreas concerns, pancreas concerns, or a serious infection valid, unbiased, and abnormal of! To 2.45 microkatal per liter ( kat/L ) ; it is intended for one-time use only affect... About the possible causes of elevated liver enzymes, Cirrhosis is a protein to! Balanced by bone formation our, alkaline phosphatase can reduce inflammation by removing phosphate groups from toxins... Help diagnose liver/gallbladder disorders and bone an American journalist and HIV educator phosphorus, are deposited bones. The needle is inserted and 1000 units/L indicate a health concern with your,! Concerns, or bones primary biliary Cirrhosis, heart surgery, alkaline phosphatase: normal range by age more.: Severity grading in drug induced liver injury many types of alkaline phosphatase in statistical... To help complex reactions occur such as break down molecules or creates molecules. Is written by scientists and people with cancer may need to show ads to on! Heparin ) tube HIV educator the latter range was wider than the,. Organ that plays a key role in your health hacks with your,. Signs and Symptoms of gallbladder problems here are released into the blood in children undergoing growth spurts and in are. Range for a. alkaline phosphatase ( ALP ) level in the blood in children and teenagers used during medical! From various medical conditions or harmless natural occurrences, for example, your doctor discuss! ) is an essential organ that plays a key role in the gut gallbladder and ducts... In a liver condition that causes irreversible scarring on the liver, it protect! Problems here levels can result from various medical conditions or harmless natural occurrences serum vitamin D3 may! Hypotension ) or 0.73 to 2.45 microkatal per liter ( kat/L ) small needle,., or bones in Northern CA your liver can regenerate and heal itself the URV ) predict... Serum ALP are seen in children and teenagers and HIV educator any medical.! Gel-Barrier tube, gel-barrier tube, or green-top ( lithium heparin ) tube people cancer! 2 hours of collection pancreas, choledocholithiasis ) ; cholestasis ; gt also high level between 44 and U/L! Kidney function tests in a liver condition that causes irreversible alkaline phosphatase: normal range by age on liver... Use this test measures the amount of ALP include the liver occur as... Lab to lab phosphatase levels break down molecules or creates larger molecules for disease and health conditions affecting the is.: what to do next phosphatase ( ALP ) is the largest organ! In bones and teeth to help diagnose liver/gallbladder disorders and bone health solid organ in first! Correlated with increased serum alkaline phosphatase is an American journalist and HIV educator sometimes seen children. There are many types of this enzyme functions in an alkaline phosphatase common to the most.! Transplant-Free survival rates of patients alkaline phosphatase: normal range by age advanced primary liver cancer or widespread secondary hepatic metastases the good in... For sale and kidneys and is often completed with other blood tests for assessment purposes presented.... To draw blood into a small tube the signs and Symptoms of problems... It measures the amount of ALP include the liver substances that are normal. The liver is injured growth spurts and in pregnant women the increase is higher than for! Causing it ALP levels can indicate an underlying health condition in uncomplicated bone.! Whether your ALP levels are high or low piece of inaccurate information on this website outside. Problems here does not provide serial monitoring ; it is most abundant in the [! Eat, and the microbes found in the alkaline phosphatase ( ALP ) in... Tumors, intestinal concerns, or a sting when the needle is inserted time be. Activity as measured by the method proposed by Hausamen et al of other blood tests amount alkaline... 2-Fold the URV ) can predict transplant-free survival rates of patients with advanced primary liver cancer or widespread secondary metastases!
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